Code reset Summary of 2025 ICD-10 changes
Make sure your practice is prepared to navigate the ICD-10 updates that take place, effective Oct. 1 annually.
Make sure your practice stays updated with the latest changes in the ICD-10-CM coding and reporting guidelines that take effect Oct. 1 annually. These codes are overseen by the (CDC) National Center for Health Statistics (NCHC) under the authorization of the World Health Organization and were developed for the Centers for Medicare and Medicaid Services (CMS).
The AOA provides the following information and resources to assist osteopathic physicians in navigating the latest revisions to the ICD-10 code set, the medical classification list of diagnosis codes for diseases, signs and symptoms, complaints, abnormal findings and external causes of injury or disease.
View the AOA’s on-demand webinar for additional information on recent ICD-10 updates.
New codes for 2025
CMS has issued the latest updates to the ICD-10-CM code set, which took effect for services provided between Oct. 1, 2024, and Sept. 30, 2025. In 2025 there were significant changes, with 252 new codes, 13 altered existing codes and 36 deleted codes.
The full list of changes can be found on the CMS website.
New codes include:
- 63 lymphoma codes of which 35 are converted to parent codes and expanded with fifth character ‘A’ to indicate cancer “in remission”
- 1 code for Fanconi anemia
- 16 codes to report presymptomatic type 1 diabetes mellitus, hypoglycemia levels, carcinoid syndrome obesity class and others
- 26 codes for anorexia, bulimia and binge-eating disorders
- 7 codes involving the nervous system; KCNQ2, serotonin syndrome, other disorders of the autonomic nervous system and developmental and epileptic encephalopathy
- 4 codes involving the circulatory system; cement or fat embolism of pulmonary artery
- 7 codes encompassing nasal valve collapse
- 27 codes for anal fistula
- 8 codes associated to cholestatic pruritus and alopecia
- 33 codes related to discogenic low back pain, multifidus muscle dysfunction, synovitis and tenosynovitis
- 4 codes involving congenital malformations of aortic and mitral valves
- 1 new code for anosognosia
- 30 codes for adverse effects of immune checkpoint inhibitor immunotherapy and disruption of gastrointestinal tract anastomosis
- 25 codes encompassing pediatric obesity body mass index, personal history of colon polyps and codes pertinent to Social Determinants of Health (SDOH)
Details by chapter
Chapter 1: Certain Infectious and Parasitic Diseases (A00-B99)
Number of deleted codes: 0
Number of revisions: 1
- A77.41 Ehrlichiosis chaffeensis (E. chaffeensis)
Number of new codes: 0
Chapter 2: Neoplasms (C00-D49)
Number of deleted codes: 14
- 39 Diffuse large B-cell lymphoma, extranodal and solid organ sites
- 0 Extranodal NK/T-cell lymphoma, nasal type
- 1 Hepatosplenic T-cell lymphoma
- 2 Enteropathy-type (intestinal) T-cell lymphoma
- 3 Subcutaneous panniculitis-like T-cell lymphoma
- 4 Blastic NK-cell lymphoma
- 5 Angioimmunoblastic T-cell lymphoma
- 6 Primary cutaneous CD30-positive T-cell proliferations
- 0 Waldenstrom macroglobulinemia
- 2 Heavy chain disease
- 3 Immunoproliferative small intestinal disease
- 4 Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue [MALT-lymphoma]
- 8 Other malignant immunoproliferative diseases
- 9 Malignant immunoproliferative disease, unspecified
Number of revisions: 0
Number of new codes: 63
- 0A- C81.9A are converted to parent codes and expanded with fifth character ‘A’ to indicate cancer “in remission” (7)
- 0A- C82.9A are converted to parent codes and expanded with fifth character ‘A’ to indicate cancer “in remission” (9)
- 0A-C83.9A are converted to parent codes and expanded with fifth character ‘A’ to indicate cancer “in remission” (7)
- 390 Primary central nervous system lymphoma
- 398 Diffuse large B-cell lymphoma of other extranodal and solid organ sites
- 0A-C84.9A are converted to parent codes and expanded with fifth character ‘A’ to indicate cancer “in remission” (8)
- 0A- C85.9A are converted to parent codes and expanded with fifth character ‘A’ to indicate cancer “in remission” (4)
- 00 Extranodal NK/T-cell lymphoma, nasal type not having achieved remission
- 01 Extranodal NK/T-cell lymphoma, nasal type, in remission
- 10 Hepatosplenic T-cell lymphoma not having achieved remission
- 11 Hepatosplenic T-cell lymphoma, in remission
- 20 Enteropathy-type (intestinal) T-cell lymphoma not having achieved remission
- 21 Enteropathy-type (intestinal) T-cell lymphoma, in remission
- 30 Subcutaneous panniculitis-like T-cell lymphoma not having achieved remission
- 31 Subcutaneous panniculitis-like T-cell lymphoma, in remission
- 40 Blastic NK-cell lymphoma not having achieved remission
- 41 Blastic NK-cell lymphoma, in remission
- 50 Angioimmunoblastic T-cell lymphoma not having achieved remission
- 51 Angioimmunoblastic T-cell lymphoma, in remission
- 60 Primary cutaneous CD30-positive T-cell proliferations not having achieved remission
- 61 Primary cutaneous CD30-positive T-cell proliferations, in remission
- 00 Waldenström macroglobulinemia not having achieved remission
- 01 Waldenström macroglobulinemia, in remission
- 20 Heavy chain disease not having achieved remission
- 21 Heavy chain disease, in remission
- 30 Immunoproliferative small intestinal disease not having achieved remission
- 31 Immunoproliferative small intestinal disease, in remission
- 40 Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue [MALT-lymphoma] not having achieved remission
- 41 Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue [MALT-lymphoma], in remission
- 80 Other malignant immunoproliferative diseases not having achieved remission
- 81 Other malignant immunoproliferative diseases, in remission
- 90 Malignant immunoproliferative disease, unspecified not having achieved remission
- 91 Malignant immunoproliferative disease, unspecified, in remission
Chapter 3: Diseases of the Blood and Blood-Forming Organs and Certain Disorders Involving the Immune Mechanism (D50-D89)
Number of deleted codes: 0
Number of revisions: 0
Number of new codes: 1
Chapter 4: Endocrine, Nutritional and Metabolic Diseases (E00-E89)
Number of deleted codes: 2
- 0 Carcinoid syndrome
- 8 Other obesity
Number of revisions: 0
Number of new codes: 16
- E10.A0 Type 1 diabetes mellitus, presymptomatic, unspecified
- E10.A1 Type 1 diabetes mellitus, presymptomatic, Stage 1
- E10.A2 Type 1 diabetes mellitus, presymptomatic, Stage 2
- E16.A1 Hypoglycemia level 1
- E16.A2 Hypoglycemia level 2
- E16.A3 Hypoglycemia level 3
- E34.00 Carcinoid syndrome, unspecified
- E34.01 Carcinoid heart syndrome
- E34.09 Other carcinoid syndrome
- E66.811 Obesity, class 1
- E66.812 Obesity, class 2
- E66.813 Obesity, class 3
- E66.89 Other obesity not elsewhere classified
- E74.820 SLC13A5 Citrate Transporter Disorder
- E74.829 Other disorders of citrate metabolism
- E88.82 Obesity due to disruption of MC4R pathway
Chapter 5: Mental, Behavioral and Neurodevelopmental Disorders (F01-F99)
Number of deleted codes: 4
- 01 Anorexia nervosa, restricting type
- 02 Anorexia nervosa, binge eating/purging type
- 2 Bulimia nervosa
- 81 Binge eating disorder
Number of revisions: 1
- 21 Rumination disorder of infancy and childhood
Number of new codes: 26
- F50.010 Anorexia nervosa, restricting type, mild
- F50.011 Anorexia nervosa, restricting type, moderate
- F50.012 Anorexia nervosa, restricting type, severe
- F50.013 Anorexia nervosa, restricting type, extreme
- F50.014 Anorexia nervosa, restricting type, in remission
- F50.019 Anorexia nervosa, restricting type, unspecified
- F50.020 Anorexia nervosa, binge eating/purging type, mild
- F50.021 Anorexia nervosa, binge eating/purging type, moderate
- F50.022 Anorexia nervosa, binge eating/purging type, severe
- F50.023 Anorexia nervosa, binge eating/purging type, extreme
- F50.024 Anorexia nervosa, binge eating/purging type, in remission
- F50.029 Anorexia nervosa, binge eating/purging type, unspecified
- F50.20 Bulimia nervosa, unspecified
- F50.21 Bulimia nervosa, mild
- F50.22 Bulimia nervosa, moderate
- F50.23 Bulimia nervosa, severe
- F50.24 Bulimia nervosa, extreme
- F50.25 Bulimia nervosa, in remission
- F50.810 Binge eating disorder, mild
- F50.811 Binge eating disorder, moderate
- F50.812 Binge eating disorder, severe
- F50.813 Binge eating disorder, extreme
- F50.814 Binge eating disorder, in remission
- F50.819 Binge eating disorder, unspecified
- F50.83 Pica in adults
- F50.84 Rumination disorder in adults
Chapter 6: Diseases of the Nervous System (G00-G99)
Number of deleted codes: 1
- 8 Other disorders of autonomic nervous system
Number of revisions: 1
- 42 Megalencephalic leukoencephalopathy with subcortical cysts
Number of new codes: 7
- G40.84 KCNQ2-related epilepsy
- G40.841 KCNQ2-related epilepsy, not intractable, with status epilepticus
- G40.842 KCNQ2-related epilepsy, not intractable, without status epilepticus
- G40.843 KCNQ2-related epilepsy, intractable, with status epilepticus
- G40.844 KCNQ2-related epilepsy, intractable, without status epilepticus
- G90.81 Serotonin syndrome
- G90.89 Other disorders of autonomic nervous system
Chapter 7: Diseases of the Eye and Adnexa (H00-H59)
Number of deleted codes: 0
Number of revisions: 5
- H44.2A3 Degenerative myopia with choroidal neovascularization, bilateral
- H44.2B3 Degenerative myopia with macular hole, bilateral
- H44.2C3 Degenerative myopia with retinal detachment, bilateral
- H44.2D3 Degenerative myopia with foveoschisis, bilateral
- H44.2E3 Degenerative myopia with other maculopathy, bilateral
Number of new codes: 0
Chapter 8: Diseases of the Ear and Mastoid Process (H60-H95)
Number of deleted codes: 0
Number of revisions: 0
Number of new codes: 0
Chapter 9: Diseases of the Circulatory System (I00-I99)
Number of deleted codes: 0
Number of revisions: 2
- I26.93 Single subsegmental thrombotic pulmonary embolism without acute cor pulmonale
- 94 Multiple subsegmental thrombotic pulmonary emboli without acute cor pulmonale
Number of new codes: 4
- I26.03 Cement embolism of pulmonary artery with acute cor pulmonale
- I26.04 Fat embolism of pulmonary artery with acute cor pulmonale I26.95 Cement embolism of pulmonary artery without acute cor pulmonale
- I26.96 Fat embolism of pulmonary artery without acute cor pulmonale
Chapter 10: Diseases of the respiratory system (J00-J99), U07.0
Number of deleted codes: 0
Number of revisions: 0
Number of new codes: 7
- J34.8200 Internal nasal valve collapse, unspecified
- J34.8201 Internal nasal valve collapse, static
- J34.8202 Internal nasal valve collapse, dynamic
- J34.8210 External nasal valve collapse, unspecified
- J34.8211 External nasal valve collapse, static
- J34.8212 External nasal valve collapse, dynamic
- 829 Nasal valve collapse, unspecified
Chapter 11: Diseases of the digestive system (K00-K95)
Number of deleted codes: 3
- 3 Anal fistula
- 4 Rectal fistula
- 5 Anorectal fistula
Number of revisions: 1
- 9 Irritable bowel syndrome, unspecified
Number of new codes: 27
- 30 Anal fistula, unspecified
- 311 Anal fistula, simple, initial
- 312 Anal fistula, simple, persistent
- 313 Anal fistula, simple, recurrent
- 319 Anal fistula, simple, unspecified
- 321 Anal fistula, complex, initial
- 322 Anal fistula, complex, persistent
- 323 Anal fistula, complex, recurrent
- 329 Anal fistula, complex, unspecified
- 40 Rectal fistula, unspecified
- 411 Rectal fistula, simple, initial
- 412 Rectal fistula, simple, persistent
- 413 Rectal fistula, simple, recurrent
- 419 Rectal fistula, simple, unspecified
- 421 Rectal fistula, complex, initial
- 422 Rectal fistula, complex, persistent
- 423 Rectal fistula, complex, recurrent
- 429 Rectal fistula, complex, unspecified
- 50 Anorectal fistula, unspecified
- 511 Anorectal fistula, simple, initial
- 512 Anorectal fistula, simple, persistent
- 513 Anorectal fistula, simple, recurrent
- 519 Anorectal fistula, simple, unspecified
- 521 Anorectal fistula, complex, initial
- 522 Anorectal fistula, complex, persistent
- 523 Anorectal fistula, complex, recurrent
- 529 Anorectal fistula, complex, unspecified
Chapter 12: Diseases of the Skin and Subcutaneous Tissue (L00-L99)
Number of deleted codes: 3
- 8 Other pruritus
- 1 Lichen planopilaris
- 8 Other cicatricial alopecia
Number of revisions: 0
Number of new codes: 8
- 81 Cholestatic pruritus
- 89 Other pruritus
- 10 Lichen planopilaris, unspecified
- 11 Classic lichen planopilaris
- 12 Frontal fibrosing alopecia
- 19 Other lichen planopilaris
- 81 Central centrifugal cicatricial alopecia
- 89 Other cicatricial alopecia
Chapter 13: Diseases of the Musculoskeletal System and Connective Tissue (M00-M99)
Number of deleted codes: 3
- 36 Other intervertebral disc degeneration, lumbar region
- 37 Other intervertebral disc degeneration, lumbosacral region
- 9 Synovitis and tenosynovitis, unspecified
Number of revisions: 0
Number of new codes: 33
- 360 Other intervertebral disc degeneration, lumbar region with discogenic back pain only
- 361 Other intervertebral disc degeneration, lumbar region with lower extremity pain only
- 362 Other intervertebral disc degeneration, lumbar region with discogenic back pain and lower extremity pain
- 369 Other intervertebral disc degeneration, lumbar region without mention of lumbar back pain or lower extremity pain
- 370 Other intervertebral disc degeneration, lumbosacral region with discogenic back pain only
- 371 Other intervertebral disc degeneration, lumbosacral region with lower extremity pain only
- 372 Other intervertebral disc degeneration, lumbosacral region with discogenic back pain and lower extremity pain
- 379 Other intervertebral disc degeneration, lumbosacral region without mention of lumbar back pain or lower extremity pain
- 85 Dysfunction of the multifidus muscles, lumbar region
- 90 Unspecified synovitis and tenosynovitis, unspecified site
- 911 Unspecified synovitis and tenosynovitis, right shoulder
- 912 Unspecified synovitis and tenosynovitis, left shoulder
- 919 Unspecified synovitis and tenosynovitis, unspecified shoulder
- 921 Unspecified synovitis and tenosynovitis, right upper arm
- 922 Unspecified synovitis and tenosynovitis, left upper arm
- 929 Unspecified synovitis and tenosynovitis, unspecified upper arm
- 931 Unspecified synovitis and tenosynovitis, right forearm
- 932 Unspecified synovitis and tenosynovitis, left forearm
- 939 Unspecified synovitis and tenosynovitis, unspecified forearm
- 941 Unspecified synovitis and tenosynovitis, right hand
- 942 Unspecified synovitis and tenosynovitis, left hand
- 949 Unspecified synovitis and tenosynovitis, unspecified hand
- 951 Unspecified synovitis and tenosynovitis, right thigh
- 952 Unspecified synovitis and tenosynovitis, left thigh
- 959 Unspecified synovitis and tenosynovitis, unspecified thigh
- 961 Unspecified synovitis and tenosynovitis, right lower leg
- 962 Unspecified synovitis and tenosynovitis, left lower leg
- 969 Unspecified synovitis and tenosynovitis, unspecified lower leg
- 971 Unspecified synovitis and tenosynovitis, right ankle and foot
- 972 Unspecified synovitis and tenosynovitis, left ankle and foot
- 979 Unspecified synovitis and tenosynovitis, unspecified ankle and foot
- 98 Unspecified synovitis and tenosynovitis, other site
- 99 Unspecified synovitis and tenosynovitis, multiple sites
Chapter 14: Diseases of the Genitourinary System (N00-N99)
Number of deleted codes: 0
Number of revisions: 0
Number of new codes: 0
Chapter 15: Pregnancy, Childbirth and the Puerperium (O00-O9A)
Number of deleted codes: 0
Number of revisions: 0
Number of new codes: 0
Chapter 16: Certain Conditions Originating in the Perinatal Period (P00-P96)
Number of deleted codes: 0
Number of revisions: 0
Number of new codes: 0
Chapter 17: Congenital Malformations, Deformations and Chromosomal Abnormalities (Q00-Q99)
Number of deleted codes: 1
- Q23.8 Other congenital malformations of aortic and mitral valves
Number of revisions: 1
Number of new codes: 4
- Q23.81 Bicuspid aortic valve
- Q23.82 Congenital mitral valve cleft leaflet
- Q23.88 Other congenital malformations of aortic and mitral valves
- Q87.86 Kleefstra syndrome
Chapter 18: Symptoms, Signs and Abnormal Clinical and Laboratory Findings, Not Elsewhere Classified (R00-R99)
Number of deleted codes: 0
Number of revisions: 0
Number of new codes: 1
Chapter 19: Injury, Poisoning and Certain Other Consequences of External Causes (S00-T88)
Number of deleted codes: 3
- 32XA Disruption of internal operation (surgical) wound, not elsewhere classified, initial encounter
- 32XD Disruption of internal operation (surgical) wound, not elsewhere classified, subsequent encounter
- 32XS Disruption of internal operation (surgical) wound, not elsewhere classified, sequela
Number of revisions: 0
Number of new codes: 30 (these include a seventh character extension that further classifies cases into initial encounters, frequent/recurrent encounters and encounters for long-term sequelae management)
- T45.AX1 Poisoning by immune checkpoint inhibitors and immunostimulant drugs, accidental (unintentional) (3)
- T45.AX2 Poisoning by immune checkpoint inhibitors and immunostimulant drugs, intentional self-harm (3)
- T45.AX3 Poisoning by immune checkpoint inhibitors and immunostimulant drugs, assault (3)
- T45.AX4 Poisoning by immune checkpoint inhibitors and immunostimulant drugs, undetermined (3)
- T45.AX5 Adverse effect of immune checkpoint inhibitors and immunostimulant drugs (3)
- T45.AX6 Underdosing of immune checkpoint inhibitors and immunostimulant drugs (3)
- T81.320 Disruption or dehiscence of gastrointestinal tract anastomosis, repair, or closure (3)
- T81.321 Disruption or dehiscence of closure of internal operation (surgical) wound of abdominal wall muscle or fascia (3)
- T81.328 Disruption or dehiscence of closure of other specified internal operation(surgical) wound (3)
- T81.329 Deep disruption or dehiscence of operation wound, unspecified (3)
Chapter 20: External Causes of Morbidity (V00-Y99)
Number of deleted codes: 0
Number of revisions: 0
Number of new codes: 0
Chapter 21: Factors Influencing Health Status and Contact With Health Services (Z00-Z99)
Number of deleted codes: 2
- Z59.7 Insufficient social insurance and welfare support
- Z86.010 Personal history of colonic polyps
Number of revisions: 1
- 54 Body mass index [BMI] pediatric, 95th percentile for age to less than 120% of the95th percentile for age
Number of new codes: 25
- Z15.1 Genetic susceptibility to epilepsy and neurodevelopmental disorders
- Z15.2 Genetic susceptibility to obesity
- Z17.21 Progesterone receptor positive status
- Z17.22 Progesterone receptor negative status
- Z17.31 Human epidermal growth factor receptor 2 positive status
- Z17.32 Human epidermal growth factor receptor 2 negative status
- Z17.410 Hormone receptor positive with human epidermal growth factor receptor 2positive status
- Z17.411 Hormone receptor positive with human epidermal growth factor receptor 2negative status
- Z17.420 Hormone receptor negative with human epidermal growth factor receptor 2positive status
- Z17.421 Hormone receptor negative with human epidermal growth factor receptor 2negative status
- Z51.A Encounter for sepsis aftercare
- Z59.71 Insufficient health insurance coverage
- Z59.72 Insufficient welfare support
- Z67.A1 Duffy null
- Z67.A2 Duffy a positive
- Z67.A3 Duffy b positive
- Z67.A4 Duffy a and b positive
- Z68.55 Body mass index [BMI] pediatric, 120% of the 95th percentile for age to less than140% of the 95th percentile for age
- Z68.56 Body mass index [BMI] pediatric, greater than or equal to 140% of the 95th percentile for age
- Z83.72 Family history of familial adenomatous polyposis
- Z86.0100 Personal history of colon polyps, unspecified
- Z86.0101 Personal history of adenomatous and serrated colon polyps
- Z86.0102 Personal history of hyperplastic colon polyps
- Z86.0109 Personal history of other colon polyps
- Z92.26 Personal history of immune checkpoint inhibitor therapy
Chapter 22: Codes for Special Purposes (U00-U85)
Number of deleted codes: 0
Number of revisions: 0
Number of new codes: 0
Official sources of information
CMS provides access to the official ICD-10-CM code set and guidelines.
Next steps
These changes are now in effect and must be used on claims for all services delivered Oct.1, 2024 – Sept. 30, 2025. Look for the next update Oct. 1, 2025.
What are the key actions that provider practices should take?
- Review changes in codes and guidelines for your range of practice
Focus first on the codes you use most in your practice, then review changes for the others.
- Adjust documentation as necessary
Your documentation processes may need to be changed so that you have the information needed to use the new codes. Review how you document and revise as necessary.
- Alert physicians
- Train staff
Make sure all staff involved in documentation, coding and billing are aware of these changes and adjust as necessary. Review the changes with them and note any processes that need to be updated.
- Assure that software is up to date for these changes
Check with your software vendors to ensure they have incorporated the new ICD-10-CM codes in your products. Test the products by entering the new codes and see if they work. If your software has not been updated, contact your vendor immediately to get the updates.
- Review any instructions from health plans
Individual health plans may have updated their coverage and billing guidelines to take these new codes into account.
- Monitor for future changes
Remember that there are coding changes every year, so keep up to date. There may be new codes issued during the year, as well as the major change each Oct. 1.