Chronic Pain Management Provided by Osteopathic vs. Allopathic Physicians: Comparison of Patient-Reported Outcomes Over 36 Months | John C. Licciardone, DO, MS, MBA, is the first recipient of a Regents Professorship awarded by University of North Texas Health Science Center/Texas College of Osteopathic Medicine and holds the Osteopathic Heritage Foundation Distinguished Chair in Clinical Research. He directs the Osteopathic Research Center and its national pain research registry, PRECISION. He received a Midcareer Investigator Award from the National Institutes of Health (NIH) and later served as an NIH expert panelist and on its National Advisory Council for Complementary and Integrative Health. He directed the OSTEOPATHIC Trial funded by NIH that showed OMT efficacy. He served to help develop NIH’s Federal Pain Research Strategy and is a co-investigator in the $14 million PACBACK Trial sponsored by NIH. He served as a World Health Organization consultant on international regulatory and safety issues relating to osteopathy. He gave the keynote address at Advancing Osteopathy 2008 to celebrate recognition of osteopaths in the UK’s National Health Service, including a reception with His Royal Highness, then-Prince of Wales, King Charles III. He advised two U.S. Surgeons General on the role of osteopathic physicians in American health care. The American Osteopathic Foundation honored Dr. Licciardone with its Gutensohn-Denslow Award for devoted lifetime service and contributions to research and education.
Executive summary:
Osteopathic physicians take a whole-person approach to medical care that may be seen in their relationships with patients and may involve using osteopathic manipulative treatment as an alternative to opioid therapy in patients with chronic pain. This study aimed to compare the outcomes of patients with chronic low back pain (CLBP) treated by osteopathic and allopathic physicians in the United States using a pragmatic design reflecting medical care in real-world settings, including an assessment of potential mediators of osteopathic medical care.
A retrospective cohort study was conducted using patients with CLBP selected from the Pain Registry for Epidemiological, Clinical and Interventional Studies and Innovation (PRECISION) from September 2016 through September 2024. Patients were followed at quarterly encounters for up to 36 months after PRECISION enrollment to determine if they were receiving their CLBP medical care from either osteopathic or allopathic physicians. Outcomes pertaining to pain, function, pain impact, health-related quality of life and the frequency of chronic widespread pain and CLBP recovery were also measured at these encounters using generalized estimating equations. Results were adjusted for sociodemographic and clinical characteristics in multivariable analyses. Regression-based analyses were used to determine if osteopathic manipulative treatment, opioid prescribing or physician empathy mediate the outcomes of osteopathic medical care.
There were 1491 patients in the study, including 278 (18.6%) and 1213 (81.4%) treated by osteopathic and allopathic physicians, respectively. A total of 8854 encounters were completed over 36 months, including 2107 (23.8%) and 6747 (76.2%) in the osteopathic and allopathic medical care groups, respectively. The adjusted means (95% CIs) for patients treated by osteopathic vs allopathic physicians were 6.3 (6.0-6.6) vs 6.5 (6.3-6.7) for low back pain intensity (P=0.05); 14.8 (13.8-15.8) vs. 15.6 (14.8-16.4) for back-related disability (P=0.008); 31.9 (30.6-33.2) vs. 32.7 (31.7-33.7) for pain impact (P=0.07); and 57.8 (56.7-58.8) vs. 58.4 (57.6-59.3) for HRQOL deficits (P=0.04). The frequency of CWP occurrence (RR, 1.00; 95% CI, 0.87-1.15; P=0.98) and CLBP recovery (RR, 0.65; 95% CI, 0.38-1.11; P=0.12) did not differ between the osteopathic and allopathic medical care groups after adjusting for potential confounders. The significant results pertaining to pain, function and HRQOL were consistently and most strongly mediated by physician empathy and to a lesser extent by osteopathic manipulative treatment.
This study found that patients with CLBP treated by osteopathic physicians reported better outcomes for pain, function and HRQOL than patients treated by allopathic physicians over 36 months of follow-up. These effects of osteopathic medical care were most consistently and strongly mediated by physician empathy and, to a lesser extent, by OMT. Osteopathic medical care was not associated with decreased CWP occurrence or increased CLBP recovery. Future research should explore other aspects of osteopathic medical care that may mediate better outcomes pertaining to pain, function and HRQOL.