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Life + Career Osteopathic Research Funded Research Projects

Funded Research Projects

Paying it forward

Grant funding supports osteopathic research in five key areas

Get to know the projects and researchers whose work has earned AOA funding.

During the past three years, the AOA has awarded more than $4 million in grants to fund 42 research projects focused on evaluating the effectiveness of osteopathic medicine in five key areas: osteopathic philosophy, chronic diseases and conditions, OMM/OMT, musculoskeletal injuries and prevention, and pain management.

Learn more about grant opportunities for physicians and fellows, residents and osteopathic medical students. Grant periods range from 6 to 24 months and recipients are strongly encouraged to submit their research for publication in The Journal of the American Osteopathic Association.

Meet the 2019 grant recipients and learn about other AOA-funded research projects since the program began in 2016. View detailed bios.

*Completed AOA Research Projects


2019 Research Grant Recipients

Jennifer Ashley Belsky, DO, MS

Exploring Osteopathic Medicine as an Effective Adjunctive Therapy for Pediatric Oncology Patients (OMET) | Dr. Belsky is a hematology/oncology/BMT physician fellow at Nationwide Children’s Hospital in Columbus, Ohio, and a graduate of the Ohio University Heritage College of Osteopathic Medicine. Her current research focuses on providing better supportive care options for children suffering from chemotherapy side effects. Special funding for this project was provided by the Dale Dodson Educational Fund.

Kyle Burke, OMS-II

Kyle BurkeThe Effect of Facial Effleurage on Complement C3 in Patients with Acute Rhinosinusitis | Student Doctor Burke is a second-year osteopathic medical student at the Edward Via College of Osteopathic Medicine–Carolinas Campus, where he is working with Jillian Bradley, PhD, as an osteopathic student researcher on her project “The Effect of Facial Effleurage on Acute Rhinosinusitis.” Special funding for this project was provided by the Dale Dodson Educational Fund.

Blaise M. Costa, PhD

Blaise M. Costa, PhDClearance of Brain Metabolic Waste in a Natural Animal Model of Alzheimer’s Disease by Cranial Osteopathic Manipulation | Dr. Costa is an associate professor of pharmacology at Edward Via College of Osteopathic Medicine in Virginia. He received a PhD degree in Psychopharmacology from the National Institute of Mental Health and Neurosciences, India in 2005. In this AOA funded project, Costa and his co-workers will study the molecular mechanism of Cranial Osteopathic Manipulative Medicine (COMM) and its potential to serve as an adjunct treatment strategy for Alzheimer’s disease.

Charles Defendorf, DO, PGY-II

Umbilical and Amniotic Fluid Stem Cell Injections for the Management of Chronic Spine Facet Pain | Dr. Defendorf is an Internal Medicine resident physician at Bluefield Regional Medical Center and a graduate of Rowan University School of Osteopathic Medicine. During medical school, he pursued research interests including a double-blinded study to investigate osteopathic pedal pump efficacy for leg edema. Special funding for this project was provided by the Dale Dodson Educational Fund.

Alicia Ford, PhD

Effects of OMT on Biomarkers and Substance Abuse Treatment Outcomes in Patients with Chronic Pain and Opioid Abuse | Dr. Ford is a Clinical Assistant Professor at Oklahoma State University Center for Health Sciences in the Department of Psychiatry & Behavioral Sciences. Her clinical and research interests include the cognitive effects of medical and psychiatric disorders and cognitive improvement interventions for persons with substance abuse disorders.

Joseph Christopher Gigliotti, PhD

Determining the Effect of Biological Sex and Therapy on Diet-Induced Alterations in Liver and Kidney Health in Mice | Dr. Gigliotti is an Assistant Professor of Physiology at Liberty University College of Osteopathic Medicine. He has received recognition for past research projects from several organizations, including the Institute of Food Technologists and National Kidney Foundation. Dr. Gigliotti’s current research is focused on understanding the immunopathology of kidney and liver diseases and how poor diet influences these processes.

Bhuma Krishnamachari, PhD

Bhuma Krishnamachari, PhDPredictors of Stress, Anxiety, and Depression in Female Osteopathic Medical Students: A Prospective Cohort Study | Dr. Krishnamachari serves as Assistant Dean of Research and an Associate Professor of Clinical Specialties at the New York Institute of Technology College of Osteopathic Medicine. She recently completed a Health Policy Fellowship with Ohio State University. Special funding for this project was provided by the Dale Dodson Educational Fund.

Alexis Marie LaPietra, DO, FACEP, FAAEM

Alexis LaPietra, DO, FACEP. FAAEMOsteopathic Manipulative Treatment vs. Standard Therapy in the Management of Acute Neck and Low Back Pain in the Emergency Department | Dr. LaPietra is the Medical Director of the Emergency Medicine Pain Management Program and the Fellowship Director of the Emergency Medicine Pain Management Fellowship and Emergency Medicine Mental Health and Addiction Medicine Fellowship at St Joseph’s Health in Paterson, New Jersey. Co-branded award funded in collaboration with The American Osteopathic Foundation.

John C. Licciardone, DO, MS, MBA

John Licciardone, DO, MS, MBAOptimizing Chronic Pain Management through Patient Engagement with Quality of Life Measures: A Randomized Controlled Trial | Dr. Licciardone holds the Osteopathic Heritage Foundation Richards-Cohen Distinguished Chair in Clinical Research at the University of North Texas Health Science Center. He directs the Osteopathic Research Center and its PRECISION Pain Research Registry, which studies precision medicine and biopsychosocial aspects of pain.

Patrick O'Connell, OMS-IV

Role of ERAP1 in Tr1 Cell Biology and Ankylosing Spondylitis | Student Doctor O’Connell is a fourth year DO-PhD student at Michigan State University College of Osteopathic Medicine. He is working to uncover mechanisms underlying chronic autoimmune disorders, notably, Ankylosing Spondylitis. These studies will focus on the role of an important anti-inflammatory cell termed Type 1 Regulatory T cells (Tr1 cells), which potentially play an important role in joint inflammation. Special funding received from the AT Still Foundation.

Beverly A. Rzigalinski, PhD

Beverly A. Rzigalinski, PhDBiochemical Effects of Osteopathic Manipulation on Neuronal Function and Survival | Dr. Rzigalinski is a professor of Pharmacology at the Edward Via College of Osteopathic Medicine. In this current grant, she is working to decipher the biochemical effects of osteopathic manipulation on the neuron, to unravel the cellular mechanisms by which osteopathic manipulation exerts its beneficial effects on the human. Special funding received from the AT Still Foundation.

Harald Martin Stauss, MD, PhD

Harald Stauss, MD, PhDAnti-Inflammatory Actions of OMT – Role of the Cholinergic Anti-Inflammatory Reflex and Translocation of Immune Cells from Reticular Organs to the Systemic Circulation | Dr. Stauss is an Associate Professor of Pharmacology at Burrell College of Osteopathic Medicine. In the AOA-funded research project, Dr. Stauss will test the hypothesis that cranial OMT techniques elicit anti-inflammatory actions by increasing parasympathetic activity and thereby activating the cholinergic anti-inflammatory pathway. Special funding received from the Dale Dodson Educational Fund.


Past Research Grant Recipients


2018 Recipients

Kathleen Ackert, OMS-II

Leveling the Playing Field: Evaluating How Prerequisite Classes Affects Perceived Stress Levels in Medical Students
Philadelphia College of Osteopathic Medicine

Elexander Atkinson, OMS-I

Role of LPT in wound healing of colitis
Edward Via of College of Osteopathic Medicine

Jerry Balentine, DO

Meditation, Alignment with the Osteopathic Philosophy and Empathy in Osteopathic Medical Students: A Randomized Controlled Interventional Trial
New York Institute of Technology

Katrina Bantis, OMS-II

The Cardioprotective Benefits of Prolonged Fasting
New York Institute of Technology

Helena Jillian Bradley, PhD

The Effect of Facial Effleurage on Acute Rhinosinusitis
Edward Via College of Osteopathic Medicine – Carolinas Campus

Joanne DiFrancisco-Donoghue, MA, PhD

A Novel Lifestyle Intervention Program to Improve Body Composition and Chronic Disease Biomarkers in Overweight Medical Students: A Randomized Trial
New York Institute of Technology

Malinda (Mindy) Hansen, DO

Effect of Palpatory Neuromodulation of the Trigeminal Nerve for Tenderness in the Posterior Neck Musculature
University of North Texas Health Science Center/Texas COM

Lisa M. Hodge, PhD

The Effects of Lymphatic Pump Treatment on The Immune Response During Acute Pneumonia
University of North Texas Health Science Center/Texas COM

Robert E. Kessler, DO

Oral Fluid Pain Biomarkers as Objective Measures of OMT Outcomes for Cervicogenic Headache (CGH)
Touro University–Nevada

Richard Jermyn, DO

Prospective, Multicenter, Cohort Study of the Cost Effectiveness of Osteopathic Manipulative Treatment for Chronic Low Back Pain
Rowan School of Osteopathic Medicine

Alessandra Posey, DO

Effects of OMT on Return to Play Post Concussion
Nova Southeastern University

Sonia Rivera-Martinez, DO

Diabetes and OMM: A Randomized Controlled Trial
New York Institute of Technology

Kate Slaymaker, OMS-II

Inviting Interdisciplinary Input: An Osteopathic Approach to Leveraging Community Support for Prevention and Management of Chronic Disease in Rural and Appalachian Virginia
Edward Via College of Osteopathic Medicine – Virginia Campus


2017 Recipients

Elizabeth Beverly, PhD

Achieving a High Level of Wellness by Focusing on the Impact of Diabetes Distress in Rural Appalachia
Ohio University Heritage COM

Gunnar Brolinson, DO

Head Impact Biomechanics, Concussion and Osteopathic Structural Diagnosis, and Treatment
Edward Via College of Osteopathic Medicine

Hollis King, DO, PhD

Effects of Osteopathic Manipulative Treatment on Gait Biomechanics in Parkinson’s Disease
University of California, San Diego, Family Medicine and Public Health

John C. Licciardone, DO, MS, MBA

The Osteopathic Approach to Chronic Pain Management: Assessing its Biopsychosocial Processes and Relationships to Clinical Outcomes 
University of North Texas Health Science Center Texas College of Osteopathic Medicine

Rebecca Malouin, PhD, MPH, MS

Osteopathic Philosophy and Patient Experience of Care
Michigan State University

Melissa G. Pearce, DO

Reducing Inflammation with Osteopathic Treatment (RIOT Study)
Touro University–California

Venkat Venkataraman

Development of a Serum Biomarker-Based Approach to Monitor Opioid Adherence and Minimize Substance Misuse in Chronic Pain Management
Rowan University School of Osteopathic Medicine

Rebecca Wyatt, DO

The Effect of OMT on Functional Outcomes and Anti-inflammatory Biomarkers in Mild- to Moderate Traumatic Brain Injury
Michigan State University


2016 Recipients

Jennifer Berglind, PhD

Use of the Lymphatic Pump Technique as a Novel Therapy for Inflammatory Bowel Disease (IBD)
Edward Via College of Osteopathic Medicine

Walter Hartwig, PhD*

Patient Experience of Osteopathic Physician Distinction and Empathy | Walter Hartwig, PhD is an Associate Dean of Academic Affairs at Touro University College of Osteopathic Medicine in Vallejo, CA. He joined TUCOM at its inception in 1997 and has served in the roles of a faculty member (ongoing), Department Chair of Basic Sciences (2003-2009), Assistant Dean of Clinical Education (2010-2013), and Associate Dean of Academic Affairs (2013  – present). He served as Chair of Admissions from 2012-2017. He has published three books in research (The Primate Fossil Record, Cambridge University Press, 2002), teaching (Fundamental Anatomy, Lippincott, Williams and Wilkins, 2007) and service (Med School Rx: Getting In, Getting Through, and Getting On With Doctoring, Kaplan, 2009, 2011). His research interests include physical anthropology, pedagogy and the history of science.

Executive Summary: Our study examined whether patients perceive their physicians as empathetic and whether this perception is aligned with an osteopathic approach to patient care. Patient perceptions of empathy and expressions of satisfaction were measured with regard to physician behaviors that are “osteopathic” by reference to the four tenets of osteopathic principles and philosophy. Prior research has indicated that distinct aspects of osteopathic care include demonstrations of empathy and positive interpersonal and communication skills. While empathy has been studied from the physician and student perspective, it has not been studied directly in terms of how patients perceive it during an interaction with their physician. The results of this study indicate that patients are more likely to perceive their physicians as empathetic based on the degree to which their physicians treat them within an osteopathic paradigm. Patients in this study responded more positively to their interactions with physicians if the physicians adhered to osteopathic tenets.

Kendi Hensel, DO, PhD

Effects of Osteopathic Manipulation on Gait Kinematics and Postural Control in Parkinson Disease
University of North Texas Health Science Center Texas College of Osteopathic Medicine

Lori Kemper, DO, MS, FACOFP*

Osteopathic Clinical Care: A Multi-Level Analysis |
Dr. Kemper is Dean of Midwestern University, Arizona College of Osteopathic Medicine, and is a family physician at the MWU Multispecialty Clinic. Previously, she held the positions of Family Practice Program Director and Director of Medical Education at the Tempe St. Luke’s Hospital Family Practice Residency Program. She has served as dean of the Arizona College of Osteopathic Medicine at Midwestern University since 2007 and continues to practice family medicine a half-day per week at the Midwestern University Multispecialty Clinic.

Executive Summary: This project, a partnership between Midwestern University Arizona College of Osteopathic Medicine and Arizona State University Center for Health Information and Research (CHiR) uses a large database of information relating to medical care delivered to patients in Maricopa County, Arizona by DOs and MDs to compare the quality of care provided. It demonstrates that differences in training between DOs and MDs do not result in meaningful differences in care.

 

Joy H. Lewis, DO, PhD, FACP*

Prognosis ATSU-SOMA Choosing Wisely – Antibiotics | Dr. Lewis is a Professor of Public Health and Internal Medicine at A.T. Still University, School of Osteopathic Medicine in Arizona (ATSU SOMA), where she chairs the Department of Public Health and directs the National Center for Community Health Research. She is the Director of SOMA’s DO/MPH Program and Course Director for OMSII Epidemiology, Biostatistics and Preventive Medicine courses. Dr. Lewis conducts community-based applied research in her areas of interest: social determinants of health, patient safety and preventive medicine. She also focuses on research related to technology-enhanced active learning and inter-professional education. Her work in Community Oriented Primary Care (COPC) combines Public Health and Primary Care. She has mentored Students and Residents on over 100 COPC projects. Dr. Lewis is the PI representing SOMA as part of the AMA Accelerating Change in Medical Education Consortium. She is the Principal Investigator for an approximately $2 million dollar 5-year Primary Care Training Enhancement grant from the Health Resources and Services Administration (HRSA). She is also a member of the Medicare Evidence Development and Coverage Advisory Committee (MEDCAC), which provides independent guidance and expert advice to the Centers for Medicare and Medicaid Services on specific clinical topics.

Executive Summary: Researchers at ATSU-SOMA worked with Medical Joyworks to develop, disseminate, and evaluate the use of a novel mobile game application entitled “Prognosis ATSU SOMA Choosing Wisely – Antibiotics.” This was widely disseminated. Over 1,200 people utilized the app and completed at least one of the cases presented. The app was well received with the vast majority of physicians and students reporting that they felt that games such as the ones presented were helpful for them to gain knowledge related to overused treatments and procedures in general and about antibiotic stewardship specifically. Further, the majority of those who completed the evaluation felt the use of these games could improve their clinical practice, could improve the clinical practice of others, and they would like to use this platform to learn about other topics.

John C. Licciardone, DO, MS, MBA*

John Licciardone, DO, MS, MBAThe Osteopathic Difference in Treating Patients with Low Back Pain | 
Dr. Licciardone is a Regents Professor who holds the Osteopathic Heritage Foundation Richards-Cohen Distinguished Chair in Clinical Research at the University of North Texas Health Science Center. He directs the Osteopathic Research Center and its PRECISION Pain Research Registry, which studies precision medicine and biopsychosocial aspects of pain. He is a Co-Investigator in the PACBACK Trial sponsored by National Institutes of Health (NIH) and served on the Work Group that developed NIH’s Federal Pain Research Strategy. Other achievements relative to NIH include: receiving a Midcareer Investigator Award to direct the OSTEOPATHIC Trial and develop expertise in pain genetics, serving as an expert panelist in chronic pain, and completing a term on its National Advisory Council for Complementary and Integrative Health.

Internationally, he served as a consultant to the World Health Organization on regulatory and safety issues relating to osteopathy, gave the keynote address at the Advancing Osteopathy 2008 conference that celebrated recognition of osteopaths in the United Kingdom’s National Health Service (including a reception with His Royal Highness, The Prince of Wales), and has been recognized by Expertscape as the leading worldwide authority on osteopathic manipulation.

Executive Summary: This study compared perceptions of the interpersonal manner, empathy, and communication style of osteopathic physicians and allopathic physicians reported by their patients, and their clinical status and outcomes over 6 months of treatment for low back pain. A total of 313 patients in the Pain Registry for Epidemiological, Clinical, and Intervention Studies and Innovation (PRECISION Pain Research Registry) within the Osteopathic Research Center at the University of North Texas Health Science Center participated in the study from April 2016 through December 2018. Patients treated by osteopathic physicians reported more favorable perceptions of their physicians relating to interpersonal manner and empathy than did patients treated by allopathic physicians. Patients treated by osteopathic physicians also reported significantly lesser pain catastrophizing and greater pain self-efficacy than patients treated by allopathic physicians. Also, patients treated by osteopathic physicians reported lesser low back pain intensity and lesser back-related disability over 6 months. However, physician interpersonal manner, empathy, and communication style did not contribute significantly to the benefits of osteopathic medical care for low back pain. Osteopathic manipulative treatment contributed significantly to the benefits of osteopathic medical care relating to low back pain intensity and back-related functioning.

 

Natalie A. Nevins, DO, MSHPE*

Identifying Risk Factors Associated with Declining Emotional Quotient (EQ) Traits During DO Training | Dr. Nevins serves as the Assistant Dean of Clinical Education at Western University of Health Sciences/College of Osteopathic Medicine of the Pacific. She is Board Certified in Family Medicine, Neuromusculoskeletal Medicine, and Osteopathic Manipulative Medicine. She holds a Masters Degree in Health Professions Education and is a Clinical Associate Professor of Family Medicine and Clinical Professor of Neuromusculoskeletal Medicine/Osteopathic Manipulative Medicine at Western University of Health Sciences, College of Osteopathic Medicine of the Pacific. She also serves as the Medical Director for the Amrit Davaa Wellness Center in West Hollywood, CA, where she maintains her private practice in NMM/OMM. Dr. Nevins is currently a Lieutenant Colonel in the US Army Reserve serving as the Command Flight Surgeon for the Army Reserve Aviation Command.

Executive Summary: Emotional Intelligence (EI) encompasses psychosocial capacities for self-regulation. Lower EI is linked to physician burnout, which can manifest as depression, anxiety, reduced empathy, poor outcomes, and suicide. Studies suggest burnout may take root in medical school. At Western University of Health Sciences’ College of Osteopathic Medicine of the Pacific (WesternU/COMP), DO student EI trends were studied to identify risk factors. Students in DO 2014-18 were given the EQ-i online inventory, which measures 5 domains and 15 subscales. It was offered at 3 junctures: incoming, midway, and graduation. Early analyses from students in DO 2014-2016 who took all surveys showed downward trends with significant drops in Empathy and Self-Regard in the first two years. With AOA grant support, data collection continued with interest in confirming these trends. Changes took place to the curriculum impacting DO 2017-18 which served as an intervention. The main impetus was the incorporation of self-directed adult learning models to increase student responsibility for their own professional development. Results for DO 2017-18 demonstrated a new trajectory. Overall, EI, Empathy, and Self-Regard were non-significant from baseline to midway, then all increased significantly by graduation. With DO 2014-2018 combined, a distinctive downward-upward trend was revealed, with Overall EI, Empathy, and Self-Regard falling significantly, then rebounding significantly by graduation. Independence was particularly influential. DO trends were compared to findings from other health profession colleges at WesternU to include Dentistry, Podiatry, Optometry, Graduate Nursing, and Physical Therapy. Only DOs exhibited the downward-upward trend with the exception of Podiatry, which had a downward trend in their first 2 years having shared 83.5% of their curriculum with COMP. This suggests that DO students may go through a unique process of professional identity formation that involves deep levels of self-examination. While this may be desirable given their future responsibilities, if not properly addressed, it could create vulnerability. Findings further suggest that the curriculum may be influential. The prominence of Self-Regard, Empathy, and Independence suggests that self-compassion and physician autonomy may be worth investigation. Inter-institutional research is needed to determine if results reflect trends in the broader population.

Diana L. Speelman, PhD*

Use of Osteopathic Principles for Nonpharmacologic, Therapeutic Interventions in Obese Women with Polycystic Ovary Syndrome | Dr. Speelman is an Associate Professor of Biochemistry and Director of Research for the College of Medicine at Lake Erie College of Osteopathic Medicine in Pennsylvania. She earned her Ph.D. in Medical Biochemistry from the University of Maryland. Her research interests are in endocrinology and metabolism, including adipose tissue dysfunction in obesity, metabolic dysfunction in polycystic ovary syndrome (PCOS), and nonpharmacologic therapies for women with PCOS.

Executive Summary: Polycystic ovary syndrome (PCOS) is the most common hormone disorder in women of reproductive age, and it affects reproductive, cardiometabolic, and psychological health. Women with PCOS have elevated androgen levels, irregular and unpredictable menstrual cycle length, and have an elevated risk for developing obesity, insulin resistance, type 2 diabetes, cardiovascular disorders, anxiety, and depression. Acne and hirsutism are common, as is subfertility and greater risk of miscarriage. Women with PCOS also tend to exhibit hyperactivity of the sympathetic nervous system, which may exacerbate symptoms associated with the disorder. In this study, we investigated the use of non-pharmacological methods (3 months of either weekly osteopathic manipulative treatment or thrice-weekly yoga) to treat women with PCOS. Our findings can be summarized as follows: (1) Osteopathic structural assessment was able to identify increased sympathetic tone in women with PCOS, correlating with physiologic measures of sympathetic hyperactivity. Routine use of osteopathic assessment may help physicians quickly identify increased sympathetic tone in women with PCOS, and perhaps before physiologic signs manifest. (2) Weekly osteopathic manipulative treatment (OMT), including manipulation of Chapman points and rib-raising, improved some measures of sympathetic tone in women with PCOS (heart rate recovery and blood pressure post-exercise). (3) Thrice weekly yoga practice improved free testosterone and DHEA levels in women with PCOS, as well as anxiety and depression scores. Some participants also reported improved menstrual cyclicity and less acne. Together, these findings suggest that non-pharmacological treatment modalities may complement current treatment options for women with PCOS. Weekly OMT may improve some aspects of sympathetic tone, whereas regular yoga practice may help to improve some of the reproductive (menstrual cycle length), hormonal (androgen levels), and psychological (anxiety and depression) aspects of PCOS.

 

Mark Ronald Speicher, PhD, MHA

The Value of Osteopathic Clinical Care: A Multi-Level Analysis
Midwestern University Arizona College of Osteopathic Medicine

Michael V. Volin, PhD*

Lymphatic Pump Treatment of Inflammation in Rat-Adjuvant-Induced Arthritis | Dr. Michael V. Volin earned his Ph.D. in Pathology from The University of Chicago in 1996, followed by a post-doctoral fellowship at the Feinberg School of Medicine at Northwestern University until 2000. He then became a faculty member at the Illinois College of Optometry. In 2004 he moved to Midwestern University, where his research laboratory studies potential mediators and therapies of rheumatoid arthritis, and he teaches immunology and infectious disease to multiple graduate and medical professional programs. In 2011 he was appointed as Chair of the Microbiology and Immunology Department and in 2012, he was promoted to Professor. He is a member of The American Association of Immunology, The American College of Rheumatology, The American Society for Investigative Pathology, and The Association of Medical School Microbiology and Immunology Chairs. He was awarded funding from the National Institutes of Health for his work studying mediators of arthritis and The American Osteopathic Association for his work studying osteopathic manipulative therapy in rat models of arthritis. He has published over 50 articles and has been an invited speaker at national conferences.

Executive Summary: Rheumatoid arthritis (RA) is an immune-inflammatory disorder characterized by chronic inflammation. Rat adjuvant-induced arthritis (AIA) is a rodent model of RA that is well characterized to have many similarities with human RA along with dysfunctional lymphatics and aberrant cell-mediated immunity. Previous studies using rat AIA have demonstrated that an increase in circulation of T regulatory lymphocytes (Tregs) can decrease clinical parameters of arthritis. Preliminary studies suggest that the lymphatic pump technique (LPT) can successfully be applied to rats to increase lymph flow, decrease joint swelling, and inflammatory mediators. In this report, we show that lymphatic pump treatment administered prophylactically before the appearance of inflammation or arthritis in AIA rats results in decreased development of ankle swelling and other clinical symptoms of arthritis. Additionally, in this report, we show that lymphatic pump treatment of AIA rats with developing arthritis have reduced joint swelling and other clinical symptoms of arthritis. We show that the reduced clinical signs of inflammation seen in the preventative LPT animals were accompanied by a reduction of peripheral blood lymphocytes. Alternatively, in the animals that had established arthritis, LPT resulted in a significant increase in peripheral blood lymphocytes, including Tregs. This increase may be the result of freeing up the lymphocytes sequestered in the inflamed joints. Finally, ankle joint tissue from rats treated with LPT after the establishment of arthritis showed an increase in both the size and number of lymphatic vessels, however, there was no change in the expression of the primary lymphatic vessel growth factor VEGFc. In conclusion, this study shows that LPT of rats with AIA results in changes in the animals consistent with enhanced lymphatic function resulting in normalization of lymphatic flow allowing for either a reduction of the development of arthritis when given prophylactically or an increase in circulating lymphocytes, including Tregs, resulting in decreased clinical parameters of arthritis when given therapeutically.

 

Sheldon Yao, DO

Effect of Osteopathic Manipulation on Balance Function, and Biomarkers in Parkinson’s Disease
New York Institute of Technology College of Osteopathic Medicine

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