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Blood Test Uncovers Undiagnosed Diabetes in Hospital Patients with High Blood Sugar

The Journal of the American Osteopathic Association Study Finds HbA1C Test Leads to Diabetes Diagnosis for a Significant Percentage of Hospitalized Patients with Hyperglycemia

By AOA Media Team


​Journal of the American Osteopathic Association Study Finds HbA1C Test Leads to Diabetes Diagnosis for a Significant Percentage of Hospitalized Patients with Hyperglycemia

CHICAGO—May 23, 2016—A retrospective review of medical records found the HbA1C test, commonly used to diagnose and manage diabetes, can effectively detect hidden disease among hospital patients with hyperglycemia, commonly known as high blood sugar.

Hyperglycemia is a frequent finding that can be related to physiologic stress, illness and medications, including steroids and vasopressors. Researchers from Touro University California and Ohio University Heritage College of Osteopathic Medicine reviewed the medical records of 348 patients with hyperglycemia inpatients discovered at admission in a rural community teaching hospital in the Midwest. Of those patients, 50 had no known history of diabetes and 31 of them were given an HbA1C test, which measures the average blood glucose level over the previous eight to 12 weeks.

Among those tested, 77 percent had results consistent with diagnoses of diabetes (58 percent) or prediabetes (19 percent). Ultimately, more than half (55 percent) of patients with no previous history of diabetes received a discharge diagnosis that included diabetes.

“In the hospital, we often find hyperglycemia when we’re treating other illnesses, like sepsis or a heart attack. This study found that patients with no known history of diabetes whose HbA1C level was measured were five times more likely to leave the hospital with a diagnosis of new-onset diabetes,” said Dr. Shubrook.

“That shows us we are missing opportunities to detect diabetes and initiate treatment for those patients to help manage that disease, which can reduce their long-term cost of care and disease burden,” Dr. Shubrook added. “From the osteopathic perspective of early detection equals better outcomes, it’s easy to make a case for hospital protocols to trigger an HbA1C test when hyperglycemia is detected to distinguish between transient hyperglycemia and chronic disease.”

Approximately one in five health care dollars is spent on diabetes care, according to the American Diabetes Association, with the largest percentage of that cost related to inpatient care. Previous studies found that patients who receive a diabetes diagnosis and receive inpatient education have a lower all-cause 30-day hospital readmission rate.

Open access to the full review is available until August:

Disclosures: Dr. Shubrook, a JAOA associate editor, was not involved in the editorial review or decision to publish the article. Dr. Shubrook has served as a consultant for NovoNordisk, AstraZeneca, GlaxoSmithKline and Lilly. He has received research support from Sanofi.

No financial support was reported for this study.

About The Journal of the American Osteopathic Association

The Journal of the American Osteopathic Association (JAOA) is the official scientific publication of the American Osteopathic Association. Edited by Robert Orenstein, DO, it is the premier scholarly peer-reviewed publication of the osteopathic medical profession. The JAOA’s mission is to advance medicine through the publication of peer-reviewed osteopathic research.


Media Contact:   

Lauren Brush
(312) 202-8161